Aloisi Somer, Julia G. Camilotti, A. Gonçalves, Claudia B. Kniphoff da Cruz, Flavio L. Beltrame, Francielle Sato, Nelson G. C. Astrath e Andressa Novatski

Spectroscopy Letters: An International Journal for Rapid Communication – Volume: 48; Issue: 6; Pages: 427-430; DOI: 10.1080/00387010.2014.902853

In this study, photoacoustic spectroscopy was used to quantify polyvinylpyrrolidone in paracetamol samples with different proportions of polyvinylpyrrolidone. Samples with 10%, 20%, and 30% of polyvinylpyrrolidone added to pure paracetamol were used. The results showed an increase in the intensity of the characteristic bands of polyvinylpyrrolidone centered at 1450 nm and 1170 nm; the intensity of these bands increased in relation to the concentration of polyvinylpyrrolidone. The phase-resolved photoacoustic method was applied in Photoacoustic spectra to provide further information. The results show that phase-resolved photoacoustic method can provide an alternative analytical method to detect different concentrations of polyvinylpyrrolidone in paracetamol samples.