Ervin K. Lenzi , Andressa Novatski, P. V. Farago, M. A. Almeida, S. F. Zawadzki, R. Menechini Neto.

PLOS One – Volume: 11, Páginas: , Issue: DOI: 10.1371/journal.pone.0157662

We present a generalmodel based on fractional diffusion equation coupled with a kinetic equation through the boundary condition. It covers several scenarios that may be characterized by usual or anomalous diffusion or present relaxation processes on the surface with non-Debye characteristics. A particular case of this model is used to investigate the experimental data obtained from the drug release of the capsaicinoids-loaded Poly (ε-caprolactone) microparticles. These considerations lead us to a good agreement with experimental data and to the conjecture that the burst effect, i.e., an initial large bolus of drug is released before the release rate reaches a stable profile, may be related to an anomalous diffusion manifested by the system.